BLOPEPBOLANG BIOTECHNOLOGY

D-retro-inverso research peptide

FOXO4-DRI

FOXO4-DRI is investigated as a disruptor of the FOXO4-p53 interaction in senescent cells and mouse models. This is preclinical senescence research.

SKU: F410
BLOPEP vial — representative image
Representative image
Quantity per vial

Availability: To be confirmed

10-vial kit

10 × 10 mg = 100 mg / box

$669.00 / boxCalculated equivalent: $66.90 per vial. Sold by package.

Catalog price in USD.

Requested: 10 vials · 100 mg

Products subtotal$669.00

Subtotal excludes freight and taxes. Availability and final terms are confirmed in the quote. Commercial and shipping terms

Mechanism and findings →

Mechanism and findings

Mixed · Study formulation · Senescent-cell assays and mouse aging models

FOXO4–p53 interaction

The study investigated disruption of FOXO4–p53 interactions and senescent-cell apoptosis in preclinical models.

Baar et al., 2017 →

Literature findings; refer to the model and formulation studied.

Mechanism of action

FOXO4-DRI — d-retro-inverso research peptide. The literature identity must be matched to the documented chemical form and composition of the supplied material.

The FOXO4–p53 interaction was investigated as a component of senescent-cell survival. The studied peptide perturbs this interaction, with p53 nuclear exclusion and apoptosis in cell models. Mouse experiments complemented the analysis; they are not clinical evidence of human rejuvenation.

  • FOXO4/p53 interaction

Baar et al., 2017

Studied findings 1
Mixed · Study formulation

FOXO4–p53 interaction

Senescent-cell assays and mouse aging models

The study investigated disruption of FOXO4–p53 interactions and senescent-cell apoptosis in preclinical models.

View context
Study design
Original-study abstract; experimental design described in linked source
Sample scope / arm
Not extracted; consult original study
Comparator
See original-study context
Experimental context (not instructions for use)
Abstract-level extraction; full methods and tables still require review.
Source section / table / abstract
Abstract

Evidence concerns the studied material and model, not the supplied BLOPEP batch.

Baar et al., 2017

Sources and studies 1
  1. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

    Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ · 2017 · Cell

    DOI: 10.1016/j.cell.2017.02.031

Specifications and packaging

Nominal variant content; analytical results belong to the documented batch.

Material type
Peptide
SKU
F410
Container or format
vial
Amount per unit
10 mg
Units per package
10
Nominal content per package
100 mg
Source commercial specification
10 mg

Quality and analyses

Review specifications, analytical results and documentation for published batches.

Purity
>99%
Type
Declared specification

Published batches

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Storage

Consult the specific conditions in the supplied material documentation.

Delivery and commercial terms

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