BLOPEPBOLANG BIOTECHNOLOGY

Shortened spadin analogue

PE-22-28

PE-22-28 is described among shortened spadin analogues studied for TREK-1 inhibition in cellular and animal experiments.

SKU: PE10
BLOPEP vial — representative image
Representative image
Quantity per vial

Availability: To be confirmed

10-vial kit

10 × 10 mg = 100 mg / box

$149.00 / boxCalculated equivalent: $14.90 per vial. Sold by package.

Catalog price in USD.

Requested: 10 vials · 100 mg

Products subtotal$149.00

Subtotal excludes freight and taxes. Availability and final terms are confirmed in the quote. Commercial and shipping terms

Mechanism and findings →

Mechanism and findings

Mixed · Study formulation · TREK-1-expressing cells and mouse behavioral models

TREK-1 inhibition

The study evaluated PE-22-28 separately from modified analogues; results from those analogues cannot all be attributed to the unmodified peptide.

Djillani et al., 2017 →

Literature findings; refer to the model and formulation studied.

Mechanism of action

PE-22-28 — shortened spadin analogue. The literature identity must be matched to the documented chemical form and composition of the supplied material.

Patch-clamp measurements in TREK-1-expressing cells examined channel inhibition by PE-22-28 and analogues. Changes at peptide termini modified some responses. Animal behavioral and synaptic assays form another level of investigation, not demonstration of an antidepressant effect in people.

  • TREK-1

Djillani et al., 2017

Studied findings 1
Mixed · Study formulation

TREK-1 inhibition

TREK-1-expressing cells and mouse behavioral models

The study evaluated PE-22-28 separately from modified analogues; results from those analogues cannot all be attributed to the unmodified peptide.

View context
Study design
Original-study abstract; experimental design described in linked source
Sample scope / arm
Not extracted; consult original study
Comparator
See original-study context
Experimental context (not instructions for use)
Abstract-level extraction; full methods and tables still require review.
Source section / table / abstract
Abstract

Evidence concerns the studied material and model, not the supplied BLOPEP batch.

Djillani et al., 2017

Sources and studies 1
  1. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity.

    Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M · 2017 · Frontiers in pharmacology

    DOI: 10.3389/fphar.2017.00643

Specifications and packaging

Nominal variant content; analytical results belong to the documented batch.

Material type
Peptide
SKU
PE10
Container or format
vial
Amount per unit
10 mg
Units per package
10
Nominal content per package
100 mg
Source commercial specification
10 mg

Quality and analyses

Review specifications, analytical results and documentation for published batches.

Purity
>99%
Type
Declared specification

Published batches

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Storage

Consult the specific conditions in the supplied material documentation.

Delivery and commercial terms

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