BLOPEPBOLANG BIOTECHNOLOGY

Mitochondrial-derived peptide

MOTS-c

MOTS-c is a mitochondrial-derived peptide studied in cellular metabolic signaling. The cited work examines folate-cycle regulation and AMPK activation in experimental models.

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Mechanism and findings →

Mechanism and findings

Mixed · Study formulation · Cellular experiments and mouse metabolic models

Metabolic signaling

The experiments linked folate/purine metabolism to AMPK activation and evaluated metabolic responses in mice.

Lee et al., 2015 →

Literature findings; refer to the model and formulation studied.

Mechanism of action

MOTS-c — mitochondrial-derived peptide. The literature identity must be matched to the documented chemical form and composition of the supplied material.

In cellular experiments, MOTS-c affected the folate cycle and associated purine synthesis, with AMPK activation. Mouse experiments explored insulin sensitivity and metabolism during aging or high-fat feeding. These two evidence levels should be read separately.

  • Folate cycle and AMPK

Lee et al., 2015

Studied findings 1
Mixed · Study formulation

Metabolic signaling

Cellular experiments and mouse metabolic models

The experiments linked folate/purine metabolism to AMPK activation and evaluated metabolic responses in mice.

View context
Study design
Original-study abstract; experimental design described in linked source
Sample scope / arm
Not extracted; consult original study
Comparator
See original-study context
Experimental context (not instructions for use)
Abstract-level extraction; full methods and tables still require review.
Source section / table / abstract
Abstract

Evidence concerns the studied material and model, not the supplied BLOPEP batch.

Lee et al., 2015

Sources and studies 2Peptide Monographs
  1. MOTS-c — PubChem molecular identity

  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

    Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, de Cabo R, Cohen P · 2015 · Cell metabolism

    DOI: 10.1016/j.cmet.2015.02.009

Specifications and packaging

Nominal variant content; analytical results belong to the documented batch.

Material type
Peptide
Molecular formula (literature identity)
C101H152N28O22S2
Molecular weight (literature identity)
2174.6 g/mol

Quality and analyses

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Purity
>99%
Type
Declared specification

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Storage

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