BLOPEPBOLANG BIOTECHNOLOGY

Mitochondria-targeted tetrapeptide

SS-31

SS-31 is a mitochondria-targeted peptide studied for interactions with cardiolipin and mitochondrial bioenergetics in experimental ischemia.

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Mechanism and findings →

Mechanism and findings

Mixed · Study formulation · Biochemical assays and rat renal ischemia model

Cardiolipin interaction

SS-31 interacted with cardiolipin in mechanistic assays and altered mitochondrial injury endpoints in rats.

Birk et al., 2013 →

Literature findings; refer to the model and formulation studied.

Mechanism of action

SS-31 — mitochondria-targeted tetrapeptide. The literature identity must be matched to the documented chemical form and composition of the supplied material.

Interaction with cardiolipin in the inner mitochondrial membrane was investigated using a fluorescent analogue and biochemical assays. The complex affected cytochrome c peroxidase activity. Rat renal-ischemia experiments assessed mitochondrial cristae and ATP recovery without establishing a general clinical benefit.

  • Cardiolipin

Birk et al., 2013

Studied findings 1
Mixed · Study formulation

Cardiolipin interaction

Biochemical assays and rat renal ischemia model

SS-31 interacted with cardiolipin in mechanistic assays and altered mitochondrial injury endpoints in rats.

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Study design
Original-study abstract; experimental design described in linked source
Sample scope / arm
Not extracted; consult original study
Comparator
See original-study context
Experimental context (not instructions for use)
Abstract-level extraction; full methods and tables still require review.
Source section / table / abstract
Abstract

Evidence concerns the studied material and model, not the supplied BLOPEP batch.

Birk et al., 2013

Sources and studies 2Peptide Monographs
  1. SS-31 — PubChem molecular identity

  2. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin.

    Birk AV, Liu S, Soong Y, Mills W, Singh P, Warren JD, Seshan SV, Pardee JD, Szeto HH · 2013 · Journal of the American Society of Nephrology : JASN

    DOI: 10.1681/asn.2012121216

Specifications and packaging

Nominal variant content; analytical results belong to the documented batch.

Material type
Peptide
Molecular formula (literature identity)
C32H49N9O5
Molecular weight (literature identity)
639.8 g/mol

Quality and analyses

Review specifications, analytical results and documentation for published batches.

Purity
>99%
Type
Declared specification

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Storage

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