Acylated GLP-1 analogue

Semaglutide

Name: Semaglutide
Price: 39 USD

Semaglutide is an acylated GLP-1 analogue. Its discovery study describes receptor activity, albumin binding and resistance to metabolic degradation.

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Mechanism and findings →

Mechanism and findings

Mixed · Study formulation · Receptor assays and mini-pig pharmacokinetics

Molecular design

The discovery paper examined receptor activity, albumin affinity and exposure; animal pharmacokinetics must not be presented as human values.

Lau et al., 2015 →

Literature findings; refer to the model and formulation studied.

Mechanism of action

Semaglutide — acylated glp-1 analogue. The literature identity must be matched to the documented chemical form and composition of the supplied material.

The molecular design combined amino-acid substitutions and acylation to modify albumin affinity and degradation resistance while retaining GLP-1R activity. The discovery publication measured binding and pharmacokinetics in mini-pigs; those values are neither human parameters nor dosing-frequency instructions.

GLP-1R

Lau et al., 2015

Studied findings 1

Mixed · Study formulation

Molecular design

Receptor assays and mini-pig pharmacokinetics

The discovery paper examined receptor activity, albumin affinity and exposure; animal pharmacokinetics must not be presented as human values.

View context

Study design: Original-study abstract; experimental design described in linked source
Sample scope / arm: Not extracted; consult original study
Comparator: See original-study context
Experimental context (not instructions for use): Abstract-level extraction; full methods and tables still require review.
Source section / table / abstract: Abstract

Evidence concerns the studied material and model, not the supplied BLOPEP batch.

Lau et al., 2015

Sources and studies 2

Semaglutide — PubChem molecular identity
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Lau J, Bloch P, Schäffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T · 2015 · Journal of medicinal chemistry
DOI: 10.1021/acs.jmedchem.5b00726