Body-weight endpoint
The phase 2 study assessed 46-week weight change. Substantial discontinuation and gastrointestinal adverse events limit interpretation of efficacy alone.
le et al., 2024 →Dual receptor peptide agonist
Survodutide is investigated as a glucagon and GLP-1 receptor dual agonist. The linked phase 2 trial studies weight-related metabolic outcomes.

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Human study · Study formulation · Adults with BMI at least 27, without diabetes
The phase 2 study assessed 46-week weight change. Substantial discontinuation and gastrointestinal adverse events limit interpretation of efficacy alone.
le et al., 2024 →Literature findings; refer to the model and formulation studied.
Survodutide — dual receptor peptide agonist. The literature identity must be matched to the documented chemical form and composition of the supplied material.
Combined GLP-1/glucagon agonism was evaluated in a dose trial with escalation and maintenance. Planned-group analysis and analysis by exposure actually received are distinct. Discontinuations and gastrointestinal events accompany interpretation of the 46-week endpoints.
Adults with BMI at least 27, without diabetes
The phase 2 study assessed 46-week weight change. Substantial discontinuation and gastrointestinal adverse events limit interpretation of efficacy alone.
Evidence concerns the studied material and model, not the supplied BLOPEP batch.
le Roux CW, Steen O, Lucas KJ, Startseva E, Unseld A, Hennige AM · 2024 · The lancet. Diabetes & endocrinology
DOI: 10.1016/s2213-8587(23)00356-xNominal variant content; analytical results belong to the documented batch.
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