Dual receptor peptide agonist

Survodutide

Survodutide is investigated as a glucagon and GLP-1 receptor dual agonist. The linked phase 2 trial studies weight-related metabolic outcomes.

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Mechanism and findings

Human study · Study formulation · Adults with BMI at least 27, without diabetes

Body-weight endpoint

The phase 2 study assessed 46-week weight change. Substantial discontinuation and gastrointestinal adverse events limit interpretation of efficacy alone.

le et al., 2024 →

Literature findings; refer to the model and formulation studied.

Mechanism of action

Survodutide — dual receptor peptide agonist. The literature identity must be matched to the documented chemical form and composition of the supplied material.

Combined GLP-1/glucagon agonism was evaluated in a dose trial with escalation and maintenance. Planned-group analysis and analysis by exposure actually received are distinct. Discontinuations and gastrointestinal events accompany interpretation of the 46-week endpoints.

  • GLP-1R / GCGR

le et al., 2024

Studied findings 1
Human study · Study formulation

Body-weight endpoint

Adults with BMI at least 27, without diabetes

The phase 2 study assessed 46-week weight change. Substantial discontinuation and gastrointestinal adverse events limit interpretation of efficacy alone.

View context
Study design
Original-study abstract; experimental design described in linked source
Sample scope / arm
Not extracted; consult original study
Comparator
See original-study context
Experimental context (not instructions for use)
Abstract-level extraction; full methods and tables still require review.
Source section / table / abstract
Abstract

Evidence concerns the studied material and model, not the supplied BLOPEP batch.

le et al., 2024

Sources and studies 1
  1. Glucagon and GLP-1 receptor dual agonist survodutide for obesity: a randomised, double-blind, placebo-controlled, dose-finding phase 2 trial.

    le Roux CW, Steen O, Lucas KJ, Startseva E, Unseld A, Hennige AM · 2024 · The lancet. Diabetes & endocrinology

    DOI: 10.1016/s2213-8587(23)00356-x

Specifications and packaging

Nominal variant content; analytical results belong to the documented batch.

Material type
Peptide

Quality and analyses

Review specifications, analytical results and documentation for published batches.

Purity
>99%
Type
Declared specification

Published batches

Batch results have not yet been published on this page.

Storage

Consult the specific conditions in the supplied material documentation.

Delivery and commercial terms

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